Niacinamide has been shown to improve melasma symptoms in several studies, with significant reductions in melasma area and severity index scores.
This clinical trial found that niacinamide 5% gel significantly improved melasma symptoms in patients with moderate to severe melasma.
Niacinamide is a form of vitamin B3 that has been shown to be effective in treating melasma, a common skin condition characterized by patches of discoloration.
The American Academy of Dermatology provides guidance on the use of niacinamide for melasma treatment, including recommended dosages and potential side effects.
This review article discusses the current understanding of niacinamide's role in melasma pathogenesis and treatment, including its effects on melanogenesis and skin inflammation.
This systematic review and meta-analysis found that niacinamide was associated with significant improvements in melasma symptoms, with a moderate to large effect size.
The Mayo Clinic provides an overview of melasma treatment options, including niacinamide, hydroquinone, and chemical peels.
This video explains the benefits and potential side effects of using niacinamide for melasma treatment, including its effects on skin hyperpigmentation.